Comorbidity profile of chronic rhinosinusitis: a population-based study.

OBJECTIVES/HYPOTHESIS This study aimed to explore the prevalence of a broad spectrum of comorbid medical conditions among patients with chronic rhinosinusitis (CRS), using a population-based dataset. STUDY DESIGN A cross-sectional study. METHODS In total, 5,734 CRS subjects and 17,202 comparison subjects were included in this study. Separate conditional logistic regression analyses were performed to calculate the odds ratio (OR) for each of 39 medical comorbidities between subjects with and without CRS. RESULTS For 27 of the 39 study comorbidities, results showed that subjects with CRS had a statistically significantly higher OR than subjects without CRS after adjusting for sociodemographic characteristics. Ranks of the top five comorbid relationships from the strongest ORs to the lowest were as follows: asthma (OR=3.09), chronic pulmonary disease (OR=3.04), weight loss (OR=2.58), obesity (OR=2.50), and migraines (OR=2.30). CONCLUSION Our results indicate that subjects with CRS have an increased prevalence of various comorbidities. LEVEL OF EVIDENCE 3b.